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Neuroimmunology of
Host-Microbe Interaction

Research

Research

We use Drosophila to study the intricate interactions between microbes, the brain, and the immune system.

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  1. How does the brain sense the microbes?

  2. How does the brain inform the immune system about the infection?

  3. How is glia involved in it?

People

People
Features
News
News

Lab News

04/25/2025: An interplay between BAT (microbes), FLY (brain), and SPIDER (immunity) 😂.

A genius artwork by Nathan.

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04/07/2025: Welcome Supurna and Afiyfah for rotating in the lab!

04/05/2025: Nathan and Chien officially join the lab! WELCOME, our FIRST two graduate students!

01/17/2025: FIRST lab outing! New Year lunch @ Hungry's.

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01/12/2025: Our first rotation students! Weclome, Basab, Chien and Nathan!

1 1/01/2024: Welcome Matt! Our FIRST lab member!!!

publications

Selected Publications

  1. Xu, W., Rustenhoven, J., Nelson, C. A., Dykstra, T., Ferreiro, A., Papadopoulos, Z., Burnham, C.D., Dantas, G., Fremont, D. H., Kipnis, J. (2023). A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan. Neuron 111(20): 3244-3254.e3248. Featured by Science Signaling, 16(809): eadl5530.

  2. Xu, W., Bao, P., Jiang, X., Wang, H., Qin, M., Wang, R., Wang, T., Yang, Y., Lorenzini, I., Liao, L., Sattler, R., Xu, J. (2019). Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity. Brain 142, 1349-1364.

  3. Xu, W., and Xu, J. (2018). C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic Neurons. J Neurosci 38, 7741-7752.

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